Globulin Calculator

Calculate serum globulin from total protein and albumin.

Aug 31, 2026 Clinical Chemistry #albumin #globulin #total-protein #electrophoresis

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All fields required unless noted

Total protein (g/dL)

Serum albumin (g/dL)

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Enter your values and press Calculate to see the result.

Reference Ranges Used

Globulin - Adult 2–3.5 g/dL

Formula & Clinical Notes

Formula

Globulin = Total Protein − Albumin

Clinical Notes

Globulin is the difference between total protein and albumin. It is commonly elevated in chronic inflammation, autoimmune disease, and multiple myeloma, and reduced in immunodeficiency states with antibody deficiency (e.g., primary hypogammaglobulinaemia) and malnutrition.

Sources

NCBI Bookshelf — Serum Albumin and Globulin (Clinical Methods)