Calculator
England & Fraser Index Calculator
Differentiate iron deficiency anemia from beta-thalassemia trait using the England & Fraser index.
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Formula & Clinical Notes
Formula
England & Fraser Index = MCV − RBC − (5 × Hb) − 3.4
Clinical Notes
A negative England & Fraser index (below 0) suggests beta-thalassemia trait; a positive value suggests iron deficiency anemia. This screening discriminant requires confirmation with iron studies and hemoglobin analysis.
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