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MELD 3.0 Calculator

Calculate the Model for End-Stage Liver Disease 3.0 score for adult liver transplant prioritisation.

Clinical Chemistry #liver #meld #meld-3.0 #cirrhosis #transplant #prognosis
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Formula & Clinical Notes

Formula

MELD 3.0 = 1.33·(female) + 4.56·ln(Bili) + 0.82·(137−Na) − 0.24·(137−Na)·ln(Bili) + 9.09·ln(INR) + 11.14·ln(Cr) + 1.85·(3.5−Alb) − 1.83·(3.5−Alb)·ln(Cr) + 6

Clinical Notes

MELD 3.0 (Kim et al. 2021) predicts 90-day mortality for adults on the liver transplant wait list and was adopted by OPTN/UNOS for allocation in July 2023, replacing MELD-Na. It adds serum albumin and female sex to bilirubin, INR, creatinine and sodium. Bilirubin, INR and creatinine below 1.0 are floored to 1.0; creatinine is capped at 3.0 mg/dL (forced to 3.0 if dialysed twice or more in the past week); sodium is clamped to 125-137 mmol/L; albumin to 1.5-3.5 g/dL. The score is rounded to an integer and bounded to 6-40.

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