Delta Ratio Calculator

Detect mixed acid-base disorders using the delta ratio (delta gap/delta bicarbonate).

Aug 31, 2026 Fluids, Electrolytes & Acid Base #acid-base #delta-gap #delta-ratio

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Measured anion gap (mEq/L)

Serum bicarbonate (mEq/L)

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Enter your values and press Calculate to see the result.

Formula & Clinical Notes

Formula

Delta Ratio = (AG − 12) / (24 − HCO₃)

Clinical Notes

The delta ratio = (ΔAG / ΔHCO₃) with normal AG 12 and normal bicarbonate 24 mEq/L. A ratio of 1.0-2.0 suggests simple high anion gap metabolic acidosis; < 1.0 suggests a concurrent hyperchloremic acidosis; > 2.0 suggests a concurrent metabolic alkalosis or chronic respiratory acidosis.

Sources

StatPearls — Anion Gap and Non-Anion Gap Metabolic Acidosis